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Clopamide

Basic Information

  • CAS No.: 636-54-4
  • Purity: 99%
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Details

Purity 99% Min Clopamide 636-54-4 Spot Supply with Safe Transportation

  • Molecular Formula: C14H20ClN3O3S
  • Molecular Weight: 345.85
  • Appearance/Colour: White to yellowish crystalline powder 
  • Melting Point: 244-246 °C 
  • Refractive Index: 1.613 
  • PKA: 9.41±0.60(Predicted) 
  • PSA： 100.88000 
  • Density: 1.39 g/cm3 
  • LogP: 4.00500 

Clopamide(Cas 636-54-4) Usage

Manufacturing Process

To a solution of 5.5 g of 3-chlorsulfonyl-4-chlorobenzoylchloride in 20 ml chlorobenzole 3.3 g of 1-amino-cis-2,6-dimethylpiperidin-hydrochloride slowly was added at room temperature. Reaction mixture was heated to 100°-105°C during 8 h, then it was cooled to room temperature. The precipitated crystals of N-[cis-2,6-dimethyl-piperidyl-(1)]-3-chlorsulfonyl-4-chlorobenzoylamide were filtered and dried at 100°C under vacuo, then was treated by ammonium at room temperature. The obtained product was chromatographed (aluminum oxide; eluent: chloroform-methanol 9:1 and methanol-ether) to give N-[cis- 2,6-dimethylpiperidyl-(1)]-3-sulfamyl-4-chlorbenzoylamide, melting point 235°-237°C.

Therapeutic Function

Diuretic, Antihypertensive

Brand name

Aquex (Novartis).

InChI:InChI=1/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+

636-54-4 Process route

clopamide
636-54-4

clopamide

Conditions
Conditions Yield
Eintragen von 4-Chlor-3-sulfamyl-benzoylchlorid in eine Lsg. von 1-Amino-cis-2,6-dimethyl-piperidin in CHCl3/Triethylamin;
Eintragen von 4-Chlor-3-sulfamyl-benzoylchlorid in eine Lsg. von 1-Amino-cis-2,6-dimethyl-piperidin in CHCl3/Triethylamin (Raumtemp.);
ZIN<sup>(057)</sup>C<sub>00235</sub>
636-54-4,3563-77-7,17163-61-0

ZIN(057) C00235

Conditions
Conditions Yield
Eintragen von 4-Chlor-3-sulfamyl-benzoylchlorid in eine Lsg. von 1-Amino-trans-2,6-dimethyl-piperidin in CHCl3/Triethylamin (Raumtemp.);

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