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1-PHENYLPIPERAZINE DIHYDROCHLORIDE

Basic Information

  • CAS No.:4004-95-9
  • Purity:99%
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Details

Factory supply 1-PHENYLPIPERAZINE DIHYDROCHLORIDE 4004-95-9 with low price

  • Molecular Formula:C10H14N2*ClH
  • Molecular Weight:198.695
  • Vapor Pressure:0.00252mmHg at 25°C 
  • Boiling Point:287.2°C at 760 mmHg 
  • Flash Point:138.3°C 
  • PSA：15.27000 
  • LogP:2.29200 

1-PHENYLPIPERAZINE DIHYDROCHLORIDE(Cas 4004-95-9) Usage

InChI:InChI=1/C10H14N2.2ClH/c1-2-4-10(5-3-1)12-8-6-11-7-9-12;;/h1-5,11H,6-9H2;2*1H

4004-95-9 Relevant articles

Design, synthesis and anticancer activity of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-1,2,3-thiadiazoles as microtubule-destabilizing agents

Wang, Chao,Wang, Zeyu,Gao, Minghuan,Li, Yuelin,Zhang, Yujing,Bao, Kai,Wu, Yingliang,Guan, Qi,Zuo, Daiying,Zhang, Weige

, (2020/12/21)

Hereby, we report our efforts on discove...

Design, synthesis and evaluation of antiproliferative and antitubulin activities of 5-methyl-4-aryl-3-(4-arylpiperazine-1-carbonyl)-4H-1,2,4-triazoles

Wang, Chao,Li, Yuelin,Liu, Tong,Wang, Zeyu,Zhang, Yujing,Bao, Kai,Wu, Yingliang,Guan, Qi,Zuo, Daiying,Zhang, Weige

, (2020/10/12)

A series of novel 5-methyl-4-aryl-3-(4-a...

Design, synthesis and docking study of 4-arylpiperazine carboxamides as monoamine neurotransmitters reuptake inhibitors

Paudel, Suresh,Sun, Ningning,Khadka, Daulat Bikram,Yoon, Goon,Kim, Kyeong-Man,Cheon, Seung Hoon

, p. 4127 - 4135 (2018/07/21)

Rational drug design method has been use...

Design, synthesis, and systematic evaluation of 4-arylpiperazine- and 4-benzylpiperidine napthyl ethers as inhibitors of monoamine neurotransmitters reuptake

Paudel, Suresh,Min, Xiao,Acharya, Srijan,Khadka, Daulat Bikram,Yoon, Goon,Kim, Kyeong-Man,Cheon, Seung Hoon

, p. 5538 - 5546 (2018/10/09)

Two series of 4-arylpiperazine- and 4-be...

4004-95-9 Process route

bis-(2-chloroethyl)amine hydrochloride
821-48-7

bis-(2-chloroethyl)amine hydrochloride

aniline
62-53-3

aniline

1-phenylpiperazine hydrochloride
4004-95-9,70849-66-0,2210-93-7

1-phenylpiperazine hydrochloride

Conditions
Conditions Yield
at 150 ℃; for 12h;
89%
With 2-(2-methoxyethoxy)ethyl alcohol; at 150 ℃; for 12h;
89%
With 2-(2-methoxyethoxy)ethyl alcohol; at 150 ℃; for 12h;
89%
With 2-(2-methoxyethoxy)ethyl alcohol; at 150 ℃; for 12h;
89%
In diethylene glycol dimethyl ether; at 150 ℃; for 12h;
89%
In sulfolane; at 150 ℃; for 14h;
87%
In 2-(2-methoxyethoxy)ethyl alcohol; at 130 ℃; for 24h; Inert atmosphere;
71%
bis-(2-chloroethyl)amine hydrochloride; aniline; In butan-1-ol; for 30h; Reflux;
With potassium carbonate; In butan-1-ol; for 40h; Reflux;
71%
bis-(2-chloroethyl)amine hydrochloride; aniline; In butan-1-ol; for 24h; Reflux;
With potassium carbonate; In butan-1-ol; for 48h; Reflux;
71%
With potassium carbonate; In butan-1-ol; for 8h; Reflux;
With potassium carbonate; In butan-1-ol; at 150 ℃; for 0.5h; Microwave irradiation;
With potassium carbonate; In butan-1-ol; at 150 ℃; for 0.5h; Microwave irradiation;
4-phenyl-piperazine-1-carboxylic acid tert-butyl ester
77278-63-8

4-phenyl-piperazine-1-carboxylic acid tert-butyl ester

1-phenylpiperazine hydrochloride
4004-95-9,70849-66-0,2210-93-7

1-phenylpiperazine hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In diethyl ether; at 20 ℃; for 2h; Inert atmosphere;
97%
With hydrogenchloride; In methanol; at 20 ℃; for 2h; Product distribution / selectivity;

4004-95-9 Upstream products

  • 14426-21-2
    14426-21-2

    diethanolamine hydrochloride

  • 137-04-2
    137-04-2

    2-chloroaniline hydrochloride

  • 77278-63-8
    77278-63-8

    4-phenyl-piperazine-1-carboxylic acid tert-butyl ester

  • 821-48-7
    821-48-7

    bis-(2-chloroethyl)amine hydrochloride

4004-95-9 Downstream products

  • 253446-34-3
    253446-34-3

    4-phenyl-piperazine-1-carboxylic acid ethyl ester

  • 57498-25-6
    57498-25-6

    N-phenyl-N′-ethylpiperazine

  • 126921-42-4
    126921-42-4

    1-phenyl-4-<β-4-quinolyl>ethyl piperazine

  • 126921-46-8
    126921-46-8

    1-phenyl-4-(β-1-isoquinolyl)ethylpiperazine

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