What is the 4-METHOXYBENZENETHIOL?

4-METHOXYBENZENETHIOL is Colorless light yellow liquid, while it's Molecular Formula is C7H8OS. Colorless light yellow liquid 4-Methoxythiophenol is used in preparing samples for self-assembled monolayers (SAM?s) characterization and to study SAM?s effect on both n- and p-channel organic thin film transistors. It is also used in cesium fluoride-Celite catalyzed preparation of thioethers and thioesters.

What is the CAS number for 4-METHOXYBENZENETHIOL?

The CAS number of 4-METHOXYBENZENETHIOL is 696-63-9.

What is 4-METHOXYBENZENETHIOL (696-63-9) used for?

4-Methoxybenzenethiol, also known as p-methoxythiophenol, is an organic compound with the chemical formula C7H8OS. It is a colorless to light yellow liquid that is soluble in organic solvents and has a distinctive odor. The presence of the methoxy group (-OCH3) on the benzene ring and the thiol group (-SH) attached to the benzene ring gives 4-methoxybenzenethiol unique chemical properties and reactivity.InChI:InChI=1/C7H8OS/c1-8-6-2-4-7(9)5-3-6/h2-5,9H,1H3/p-1

What is the 4-METHOXYBENZENETHIOL?

4-METHOXYBENZENETHIOL is Colorless light yellow liquid, while it's Molecular Formula is C7H8OS. Colorless light yellow liquid 4-Methoxythiophenol is used in preparing samples for self-assembled monolayers (SAM?s) characterization and to study SAM?s effect on both n- and p-channel organic thin film transistors. It is also used in cesium fluoride-Celite catalyzed preparation of thioethers and thioesters.

What is the CAS number for 4-METHOXYBENZENETHIOL?

The CAS number of 4-METHOXYBENZENETHIOL is 696-63-9.

What is 4-METHOXYBENZENETHIOL (696-63-9) used for?

4-Methoxybenzenethiol, also known as p-methoxythiophenol, is an organic compound with the chemical formula C7H8OS. It is a colorless to light yellow liquid that is soluble in organic solvents and has a distinctive odor. The presence of the methoxy group (-OCH3) on the benzene ring and the thiol group (-SH) attached to the benzene ring gives 4-methoxybenzenethiol unique chemical properties and reactivity.InChI:InChI=1/C7H8OS/c1-8-6-2-4-7(9)5-3-6/h2-5,9H,1H3/p-1

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4-METHOXYBENZENETHIOL

Basic Information

CAS No.: 696-63-9
Purity: 99%

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Details

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Molecular Formula: C7H8OS
Molecular Weight: 140.206
Appearance/Colour: Colorless light yellow liquid
Vapor Pressure: 0.133mmHg at 25°C
Melting Point: 291.7-295.8 °C (decomp)
Refractive Index: n20/D 1.5831(lit.)
Boiling Point: 224.9 °C at 760 mmHg
PKA: 6.76±0.10(Predicted)
Flash Point: 89.8 °C
PSA： 48.03000
Density: 1.112 g/cm³
LogP: 1.98390

4-METHOXYBENZENETHIOL(Cas 696-63-9) Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 2637, 1984 DOI: 10.1021/jo00188a028

General Description

4-METHOXYBENZENETHIOL (also known as p-mercaptoanisole or 4-methoxythiophenol) is a thiophenol derivative featuring a methoxy group para to the thiol functionality. It serves as a nucleophilic reagent in thia-Michael addition reactions, particularly in the presence of nickel-based catalysts, enabling efficient C-S bond formation with α,β-enones under mild conditions. Its utility in such reactions highlights its relevance in synthetic organic chemistry, especially for pharmaceutical and natural product synthesis.

InChI:InChI=1/C7H8OS/c1-8-6-2-4-7(9)5-3-6/h2-5,9H,1H3/p-1

696-63-9 Relevant articles

Spontaneous substitution of azulene-derived benzylic alcohols by thiols and its application to labeling/protection of biothiols

Jin, Yu,Akagawa, Kengo,Kudo, Kazuaki

supporting information, (2021/02/27)

By mixing guaiazulene-3-methanol derivat...

Sulfur Incorporation Using Disulfanes as the Sulfur Atom Source Enabled Metal-Free Heteroannulation of 1,7-Enynes

Qin, Jing-Hao,Yu, Jiang-Xi,Li, Jin-Heng,An, De-Lie

supporting information, p. 3974 - 3979 (2019/08/01)

A new oxidative [2+2+1] heteroannulation...

Copper-Catalyzed Direct Synthesis of Aryl Thiols from Aryl Iodides Using Sodium Sulfide Aided by Catalytic 1,2-Ethanedithiol

Xue, Hongyu,Jing, Bing,Liu, Shasha,Chae, Junghyun,Liu, Yajun

, p. 2272 - 2276 (2017/10/06)

A copper-catalyzed direct and effective ...

Copper(II)-Catalyzed Single-Step Synthesis of Aryl Thiols from Aryl Halides and 1,2-Ethanedithiol

Liu, Yajun,Kim, Jihye,Seo, Heesun,Park, Sunghyouk,Chae, Junghyun

supporting information, p. 2205 - 2212 (2015/07/27)

A highly efficient transition metal-cata...

696-63-9 Process route

: 5335-87-5
4,4'-dimethoxyphenyl disulfide

: 1633007-86-9
N-methyl-N-(2-(phenylethynyl)phenyl)-methacrylamide

: 696-63-9
4-Methoxybenzenethiol

: 3393-77-9
bis(4-methoxyphenyl)sulfide

: 3a,5-dimethyl-1-phenyl-3,3a-dihydrothieno[3,4-c]quinolin-4(5H)-one

: 100-66-3
methoxybenzene

: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With tert-Butyl peroxybenzoate; triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 12h; regioselective reaction; Inert atmosphere; Schlenk technique;	88%

: 696-62-8
para-iodoanisole

: 696-63-9
4-Methoxybenzenethiol

: 3393-77-9
bis(4-methoxyphenyl)sulfide

Conditions

Conditions	Yield
para-iodoanisole; With copper(l) iodide; potassium sulfide; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere; With hydrogenchloride; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; at 40 ℃; for 5h; Inert atmosphere;	80% 11%

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